St. Inigoes, sometimes called St. Inigoes Shores, is a small, rural, unincorporated farming, fishing and crabbing community at the southern end of St. Mary's County in the U.S. state of Maryland that is undergoing a transition to small residential subdevelopment plots. Its eastern side is bordered by a number of coves and creeks that are connected to the St. Marys River, a brackish tidal river, near where it feeds into the mouth of the Potomac River and close to its entry point into the Chesapeake Bay.It is a part of the site of the first colonial settlement in Maryland and is also therefore part of the fourth colonial settlement in North America.St. Inigoes is also the site of the oldest Catholic parish in America, dating back to the 1640s. St. Ignatius Roman Catholic Church, which is located in St. Inigoes, was listed on the National Register of Historic Places in 1975. The parish is still active today.